Disease Models

Axol has over 60 different patient disease lines in stock. If you want to reliably model diseases like Alzheimer’s, Parkinson’s or ALS using human iPSC-derived cells in a dish, browse our catalog to see which lines have the genetic backgrounds and Isogenic controls to suit your needs. We provide fully defined differentiated cells from these disease lines.

Axol Disease Models


All Diseases

Axol has over 60 disease lines from patients and genetically engineered models available


Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative condition that is strongly linked with age and accounts for 60-70% of all cases of dementia.


Amyotrophic Lateral Sclerosis

Axol iPSCs are derived from patients with Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig’s disease.


Charcot-Marie-Tooth Disease

Charcot–Marie–Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body.


Dentaturobral-Pallidoluysian Atrophy

Dentatorubral-Pallidoluysian Atrophy (DRPLA) is an autosomal dominant spinocerebellar degeneration caused by an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.


Friedreich’s Ataxia

Friedreich’s ataxia (FRDA or FA) is an autosomal-recessive genetic disease caused by mutations in the FXN gene on chromosome 9, which makes a protein called frataxin.


Frontotemporal Dementia

Frontotemporal dementia (FTD) refers to a spectrum of clinical diseases that may have several different underlying pathologies.


Mucolipidosis IV

Mucolipidosis IV is a rare inherited disorder characterized by intellectual disability and caused by mutations in the gene MCOLN1.


Nasu-Hakola Disease

Associated with mutations in the TREM2 and TYROBP genes, Nasu-Hakola disease (NHD), also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy.


Parkinson’s Disease

 Parkinson’s Disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system


Huntington’s Disease

Axol has six lines derived from Huntington’s Disease patients. They are excellent models for investigating the disease and developing assays to screen potential therapies


Spinal and Bulbar Muscular Atrophy

Spinal and bulbar muscular atrophy is a debilitating neurodegenerative disorder caused by degeneration of motor neurons in the brainstem and spinal cord, and muscle wasting.


Spinocerebellar Ataxia

Spinocerebellar Ataxia is a rare inherited autosomal dominant disorder that causes progressive cerebellar ataxia.