Axol has over 60 disease lines from patients and genetically engineered models available
Disease Models
Axol Disease Models
Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative condition that is strongly linked with age and accounts for 60-70% of all cases of dementia.
Amyotrophic Lateral Sclerosis
Axol iPSCs are derived from patients with Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND) or Lou Gehrig’s disease.
Charcot-Marie-Tooth Disease
Charcot–Marie–Tooth disease (CMT) is a hereditary motor and sensory neuropathy of the peripheral nervous system characterized by progressive loss of muscle tissue and touch sensation across various parts of the body.
Dentaturobral-Pallidoluysian Atrophy
Dentatorubral-Pallidoluysian Atrophy (DRPLA) is an autosomal dominant spinocerebellar degeneration caused by an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.
Friedreich’s Ataxia
Friedreich’s ataxia (FRDA or FA) is an autosomal-recessive genetic disease caused by mutations in the FXN gene on chromosome 9, which makes a protein called frataxin.
Behavioural Variant Frontotemporal Dementia (bvFTD)
Frontotemporal dementia (FTD) refers to a spectrum of clinical diseases that may have several different underlying pathologies.
Frontotemporal Dementia
Frontotemporal dementia (FTD) refers to a spectrum of clinical diseases that may have several different underlying pathologies.
Mucolipidosis IV
Mucolipidosis IV is a rare inherited disorder characterized by intellectual disability and caused by mutations in the gene MCOLN1.
Nasu-Hakola Disease
Associated with mutations in the TREM2 and TYROBP genes, Nasu-Hakola disease (NHD), also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy.
Parkinson’s Disease
Parkinson’s Disease is a long-term degenerative disorder of the central nervous system that mainly affects the motor system
Huntington’s Disease
Axol has six lines derived from Huntington’s Disease patients. They are excellent models for investigating the disease and developing assays to screen potential therapies
Parkinsonism/Machado-Joseph Disease
Parkinsonism/Machado-Joseph Disease
Spinal and Bulbar Muscular Atrophy
Spinal and bulbar muscular atrophy is a debilitating neurodegenerative disorder caused by degeneration of motor neurons in the brainstem and spinal cord, and muscle wasting.
Spinocerebellar Ataxia
Spinocerebellar Ataxia is a rare inherited autosomal dominant disorder that causes progressive cerebellar ataxia.
