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axoCellsTM Cortical Excitatory Neurons

Description

Build high-quality neurodegenerative disease models in 14 days. 

Ensure confidence in your neural workflow with high-quality axoCellsTM cortical excitatory neurons differentiated from human induced pluripotent stem cells (iPSCs). Derived from consenting donor cord blood and fibroblasts, our cortical excitatory neurons have been specifically developed for use in mono-, co- and tri-culture models of neurodegenerative disease and for drug discovery.  

With Axol, you can rely on physiologically relevant cortical excitatory neurons that express over twelve key markers (including FOXG1, PAX6 and vimentin) and form functional synapses in twenty days. With our cortical excitatory neurons, you can build robust mono-, co- and tri-culture models with isogenic astrocytes, microglia and inhibitory interneurons to investigate neurological diseases (Alzheimer’s, Parkinson’s and Huntington’s Disease; epilepsy) and for drug screening and discovery.  

Supporting quality and consistency

Confidently carry out your neural workflow with iPSCs manufactured in our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind. 

Join our customer base of top ten biopharma and academic institutions in building robust, physiologically relevant disease models for research and drug discovery. 

axoCellsTM  Cortical Excitatory Neurons 

Donor gender Donor age Source Condition Product code Cells/vials
Male Newborn Cord blood Healthy ax0015 ≥1.5 million 
Female Newborn Cord blood Healthy ax0016 ≥1.5 million 
Male 74 Pulmonary fibroblast  Healthy ax0018 ≥1.5 million 
Female 87 Dermal fibroblast  Alzheimer’s disease  ax0111 ≥1.5 million 
Female 38 Dermal fibroblast  Alzheimer’s disease ax0112 ≥1.5 million 
Male 53 Dermal fibroblast  Alzheimer’s disease ax0113 ≥1.5 million 
Female 31 Dermal fibroblast  Alzheimer’s disease ax0114 ≥1.5 million 
Female 48 Dermal fibroblast  Huntington’s disease  ax0211 ≥1.5 million 
Female 5mo Dermal fibroblast  Epilepsy  ax0411 ≥1.5 million 
Axol-Bioscience-human-iPSC-image-x_product_image_153.jpeg

Product Highlights

  • Robust, relevant neurons that express over 12 of the key markers, including FOXG1, PAX6 and vimentin
  • Ensure confidence with high-quality cells manufactured in our ISO:9001-accredited production facility under rigorous quality control procedures
  • Designed for use in mono-, co- and tri-culture models to investigate neurodegenerative diseases and for drug discovery
  • Used by leading Biopharma and academic institutions around the world to fuel robust disease models 

We have 9 lines from 3 healthy patients, 4 Alzheimer’s disease patients, 1 Huntington’s disease patient and 1 epilepsy patient. For specific info select from the list above or send us a request at operations@axolbio.com 

Applications

Our axoCellsTM cortical excitatory neuron progenitors are suitable for investigating Alzheimer’s disease, Huntington’s disease and epilepsy and for screening candidate therapies for these diseases.

Healthy control lines are also available and can be used with high–content imaging, MEA, microfluidic and organ-on-chip (OOC) devices to measure structural and functional responses in neuronal models.

Protocols

Fully optimized cell culture reagents are available for the differentiation of progenitors into mature cortical excitatory neurons within 14 days. In addition, single media protocols, enabling co- and tri-culture of our cortical excitatory neurons with inhibitory interneurons, astrocytes and microglia provide convenient and fast culture solutions to better model human diseases in vitro. 

Quality

We maintain or exceed industry-level quality with our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience.  

All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind. 

Licenses & Consent

Axol has obtained all relevant licenses for reprogramming donor samples into iPSCs and differentiating these into cortical excitatory neurons for commercial use.  

Patient samples used to create these neurons have been ethically sourced and consented for research and commercial use. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind. 

Publications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498259/ 

Garcia-Leon JA, Vitorica J, & Gutierrez A (2019). Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. Future Medicinal Chemistry, 11(11), 1305–1322. doi: 10.4155/fmc-2018-0520 [PubMed] [CrossRef] [Google Scholar] 

Media and Reagents

Using NeurOne cortical neuron supplement, mature cerebral cortical excitatory neurons can be generated in 14 days. We also supply neural plating media,  maintenance media and SureBond –XF coating as standalone items or as a kit.