Description
Build high-quality neurodegenerative disease models in 20 days.
Ensure confidence in your neural workflow with high-quality axoCellsTM cortical excitatory neurons differentiated from human induced pluripotent stem cells (iPSCs). Derived from consenting donor cord blood and fibroblasts, our cortical excitatory neurons have been specifically developed for use in mono-, co- and tri-culture models of neurodegenerative disease and for drug discovery.
With Axol, you can rely on physiologically relevant cortical excitatory neurons that express over twelve key markers (including FOXG1, PAX6 and vimentin) and form functional synapses in twenty days. With our cortical excitatory neurons, you can build robust mono-, co- and tri-culture models with isogenic astrocytes, microglia and inhibitory interneurons to investigate neurological diseases (Alzheimer’s, Parkinson’s and Huntington’s Disease; epilepsy) and for drug screening and discovery.
Supporting quality and consistency
Confidently carry out your neural workflow with iPSCs manufactured in our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Join our customer base of top ten biopharma and academic institutions in building robust, physiologically relevant disease models for research and drug discovery.
How to get high-functioning cortical excitatory neurons:
- You’ll need a Cortical Excitatory Neuron Kit ax5115 or ax5118
- In this you’ll find neural stem cells ax0015 or ax0018 espectively and all reagents*
- Follow the protocol
- 21 days later you will have high functioning cortical excitatory neurons
*Additional third party components may be required. Be sure to check the protocol before you start using the cortical excitatory neuron kit.
| Product name | Product code | Kit code |
| axoCells™ human iPSC-derived neural stem cells (sAD, ApoE3/E3), female donor, aged 59, ≥1.5 million cells | ax0170 | ax5170 |
| axoCells™ human iPSC-derived Neural Stem Cells (sAD, ApoE3/E4), male donor, aged 60, ≥1.5 million cells | ax0174 | ax5174 |
| axoCells™ human iPSC-derived neural stem cells (sAD, ApoE3/E4), female donor, aged 52, ≥1.5 million cells | ax0177 | ax5177 |
| axoCells™ human iPSC-derived neural stem cells (sAD, ApoE4/E4), female donor, aged 69, ≥1.5 million cells | ax0108 | ax5108 |
| axoCells™ human iPSC-derived neural stem cells (sAD, ApoE3/E3), male donor, aged 80, ≥1.5 million cells | ax0109 | ax5109 |
| axoCells™ human iPSC-derived neural stem cells (sAD, ApoE4/E4), female donor, aged 76, ≥1.5 million cells | ax0110 | ax5110 |
| axoCells™ human iPSC-derived neural stem cells, unaffected male donor, aged 40-50, ≥1.5 million cells | ax0004 | ax5004 |
| axoCells™ human iPSC-derived neural stem cells (HD, CAG125), female donor, aged 7, ≥1.5 million cells | ax0219 |
Don’t see exactly the cells you’re looking for? Check out our custom manufacturing service.
Need a quote for this single product or for the whole cell + media + reagent kit? We’re here to help! Click the button below or send an email to operations@axolbio.com
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Product Highlights
- Robust, relevant neurons that express over 12 of the key markers, including FOXG1, PAX6 and vimentin
- Ensure confidence with high-quality cells manufactured in our ISO:9001-accredited production facility under rigorous quality control procedures
- Designed for use in mono-, co- and tri-culture models to investigate neurodegenerative diseases and for drug discovery
- Used by leading Biopharma and academic institutions around the world to fuel robust disease models
We have 7 lines from 3 healthy patients and 4 Alzheimer’s disease patients. For specific info select from the list above or send us a request at operations@axolbio.com
Applications
Our axoCellsTM cortical excitatory neuron progenitors are suitable for investigating Alzheimer’s disease and for screening candidate therapies for this disease.
Healthy control lines are also available and can be used with high–content imaging, MEA, microfluidic and organ-on-chip (OOC) devices to measure structural and functional responses in neuronal models.
Protocols
It is essential to follow the provided protocol and use the cells, media and supplements as described to achieve the full performance final state cell type. For additional support contact support@axolbio.com.
Quality
We maintain or exceed industry-level quality with our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience.
All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Licenses & Consent
Axol has obtained all relevant licenses for reprogramming donor samples into iPSCs and differentiating these into cortical excitatory neurons for commercial use.
Patient samples used to create these neurons have been ethically sourced and consented for research and commercial use. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Publications
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7498259/
Garcia-Leon JA, Vitorica J, & Gutierrez A (2019). Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. Future Medicinal Chemistry, 11(11), 1305–1322. doi: 10.4155/fmc-2018-0520 [PubMed] [CrossRef] [Google Scholar]
Media and Reagents
Using NeurOne cortical neuron supplement, mature cerebral cortical excitatory neurons can be generated in 20 days. We also supply neural plating media, maintenance media and SureBond –XF coating as standalone items or as a kit.
