Parkinsonism/Machado-Joseph Disease
Caused by mutations in the ATXN3 gene which produces an abnormal form of the ataxin protein, Parkinsonism/Machado-Joseph disease patients experience degeneration of cells in the hindbrain.
Axol’s Parkinsonism/Machado-Joseph disease lines are derived from patients and are excellent models for investigating the disease. Axol now offers made-to-order differentiated human iPS brain cells, such as microglia, from these MJD lines.