Description
Build high-quality in vitro neuromuscular disease models in 14 days.
Ensure confidence in your workflow with high-quality axoCellsTM motor neurons differentiated from human induced pluripotent stem cells (iPSCs). Derived from consenting donor fibroblasts, our motor neurons have been specifically developed for use in powerful in vitro monoculture and co-culture models, microfluidics platforms and for drug discovery.
With Axol, you can rely on robust, physiologically relevant motor neurons that express key markers including HB9, MAP2, LIM3 and ChAT2 within 14 days of culture using our Motor Neuron Maturation Accelerator Supplement. That means robust, physiologically relevant models of diseases such as ALS.
Supporting quality and consistency
Confidently carry out your neural workflow with iPSCs manufactured in our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Join our customer base of top ten biopharma and academic institutions in building robust, physiologically relevant disease models for research and drug discovery.
Product Highlights
- Robust, relevant neurons that express key markers, including HB9 and ChAT
- Save time with functionally mature motor neurons available in just fourteen days
- Ensure confidence with high-quality cells manufactured in our ISO:9001-accredited production facility under rigorous quality control procedures
- Designed for use in microfluidics platforms to investigate neuromuscular diseases and for drug discovery
- Used by leading Biopharma and academic institutions around the world to fuel robust microfluidics platforms and disease models
Applications
Our axoCellsTM motor neurons have been specifically developed for use in in vitro disease modeling and drug discovery. As a neuromuscular junction (NMJ) model with iPSC derived skeletal muscle, our ALS, unaffected ALS and healthy motor neurons have been used in both 2D and 3D formats to characterize and measure structural and functional phenotypic responses in vitro.
We have a community of top ten biopharma and research institutes that use our motor neurons to build powerful in vitro models, investigating neurodegenerative disorders such as ALS and for drug screening
Protocols
A fully validated protocol for accelerated maturation of motor neurons is available here.
Quality
We maintain or exceed industry-level quality with our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience.
All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Licenses & Consent
Axol has obtained all relevant licenses for reprogramming donor samples into iPSCs and differentiating these into motor neurons for commercial use.
Patient samples used to create these neurons have been ethically sourced and consented for research and commercial use. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Publications
A fully validated protocol for monoculture of microglia is available. In addition, single media protocols, enabling co- and tri-culture of our cortical excitatory neurons with astrocytes and microglia or cortical inhibitory interneurons and microglia provide convenient and fast solutions to better model human diseases in vitro.
Media and Reagents
An optimized media and all growth factors are available to mature motor neurons in culture within 14 days of thaw.
