With over a decade of experience in the human iPSC space, we understand that high-quality differentiation is challenging, with significant risks and costs if not performed well. But like you, we also see the enormous value of human iPSCs for building better, more physiologically relevant models of human disease.
That’s why we offer our iPSC expertise to leading biopharma and research organizations globally. We’ve developed a tried-and-tested workflow to provide full-service differentiation from iPSCs to end-point cells, with robust characterization and ongoing support from our expert scientists.
Clients who work with Axol share our obsession with doing it once and doing it well. We prioritize quality control and characterization, always built-in as standard in our projects, to ensure there are no surprise challenges (or costs), maximizing project success. That gives you more confidence, time and resource to focus on your research to produce better human disease models for drug discovery and beyond.
Custom Manufacturing from iPSCs to functional end-point cells
We take cell manufacturing very seriously. We see the deliverable not just cells but the essential quality, functional, consistent inputs to your in vitro system. We can manufacture from our library of 70 lines or can bring in your or a third-party’s lines. We can do small runs, very large runs, we can synchronize with your program of work to ensure availability at stock. With size, comes the quality, reproducibility and availability.
Axol is widely recognized in the market as the leader in the production of cells for neuroscience, ophthalmology, cardiology, dermatology and pain & sensation with a long list of satisfied clients from leading academic labs, CROs, through the smallest to the largest biotechs and top 10 pharma.
Manufactured cells and specialist media and supplements can be shipped directly back to you or sent to a CRO third party or used directly in our service facility for the seamless continuation of your study.
Pilot scale productions ahead of larger scale production
Send us a quick request and we’ll send you back a timeline and a cost.
Your enquiry will be reviewed by one of our Project Managers and we’ll get back to you shortly. If it’s easier, you can always message us at operations@axolbio.com
Choose an axoServicesTM Differentiation project for:
Prioritization of quality and consistency
Open discussions with actual iPSC experts
Dependable, high-quality project outcomes
“Working with AXOL has been a professional experience all around. Data was delivered on time and presented in a clear and concise fashion. Our expectations were met, and we plan to work together again.”
Dr Ian Moench, GSK
What do you get with Axol?
Step 1. Kick-off meeting with the Axol iPSC experts
Decades of experience in the room
Open, two-way communication
Rapid follow-up with competitive quote
Step 2. Extensive iPSC characterization
Flow cytometry to confirm pluripotency-associated marker expression
Ensure high-quality starting material to maximize project success
Step 3. Directed differentiation + optimization
Our proprietary directed differentiation process uses small molecules to generate footprint-free end-point cells
Built-in optimization provides safety net for project challenges
Robust target cell populations for QC, custom assays and shipping
Step 4. QC and custom assays
Rigorous checks for contaminants and optimal post-thaw viability
ICC to confirm expression lineage-specific markers
Custom assays capabilities to match project requirements
Desired end-point cells are shipped with media and instructions
Step 5. Ongoing support
Continued communication and advice from iPSC experts
Ease the adaptation of cells into your experimental system
An open channel for future projects, collaborations and partnerships
Example cases
Brief: A client would like to produce microglia for an Alzheimer’s monoculture disease model, using cells from Axol’s banks.
Project: Axol iPSC line ax0113 (derived from an Alzheimer’s patient) was already well-characterized for both cell culture performance and physiological, end-point performance. As a result, differentiation using our proprietary small molecule process went smoothly.
Outcome: Generation of 30 vials of microglia within 6 weeks (plus extensive QC). Additional custom assays (chemotaxis and phagocytosis) were performed and reported.
Brief: A client would like us to differentiate their cells into sensory neurons for use in monoculture, before consideration of co-culture.
Project: Initial characterization revealed significant quality issues with the source material. However, Axol provided advice and additional optimization steps to account for the challenges, communicating this with the client.
Outcome: Generation of 30 vials of sensory neurons in 8 weeks, plus extensive QC. By identifying and communicating challenges up-front, there was full transparency with the additional time and resources for project completion.
Our approach to collaboration
What does the ideal outsourced scientific project look like? We see ourselves as collaborators, partners, bench scientists and project managers, here to work alongside you to support and accelerate your work. And just like you, we like getting the work done efficiently and effectively, with clear open communication throughout.
We also recognise the trust you put in us to support your work, remove the heavy lifting and ensure your timelines proceed on schedule. Ultimately, we’re all progressing towards the same mission so we would be honoured to partner on your research and get closer to delivering better therapies for patients.
Our company operates through its stated values and behaviours of Performance, Accountability, Transparency, Collaboration, Diversity & Inclusion and Integrity. With a dedicated services team, we’re always on hand to support in any way we can.
We hope that we can be of service and welcome your enquiries.
Fill in the form and let us know about your special requirements
