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Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative condition that is strongly linked with age and accounts for 60-70% of all cases of dementia.
Early onset Alzheimer’s disease, which accounts for approximately 2-3% of AD cases, is a hereditary condition that is strongly associated with mutations in presenilin-1 (PSEN1), amyloid precursor protein (APP) and presenilin-2 (PSEN2) genes. Late onset Alzheimer’s disease occurs after the age of 65 and accounts for the vast majority of cases.

A combination of factors increase the risk of developing Alzheimer’s disease. One of the strongest risk factors is having two copies of the APOE4 allele, which increases the risk of developing late onset Alzheimer’s disease by approximately 15 times.

Frontotemporal dementia (FTD) refers to a spectrum of clinical diseases that may have several different underlying pathologies. Frontotemporal dementia can be sporadic or associated with mutations in the MAPT (microtubule-associated protein tau) and progranulin genes, and C9ORF72 repeat expansions.

These genetic mutations can lead to accumulation of TDP43 protein or tangles of MAPT (tau) protein. Currently, there are no approved treatments or reliable biomarkers for frontotemporal dementia. There is a need for in vitro human cell models for frontotemporal dementia and Alzheimer’s disease that can be used to accelerate research and assist in the development of new drugs to treat these disorders.

Alzheimer's Disease

Human iPSC-derived neural stem cells from Alzheimer’s disease patients

Fibroblasts from patients, clinically diagnosed with Alzheimer’s disease, were reprogrammed to iPSCs using our footprint-free episomal reprogramming method and then differentiated to neural stem cells using our chemically defined cortical neural induction method. Neural stem cells are available from Alzheimer’s patients with mutations in the presenilin-1 (PSEN1) and presenilin-2 (PSEN2) genes as well as a patient homozygous for the APOE4 allele. Neural stem cells from healthy donor iPSCs are also available as suitable controls.

Product ax0019 is the healthy isogenic control for the following cell lines:

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