Sporadic Alzheimer’s disease iPSC models
Most Alzheimer’s disease cases are sporadic rather than familial, yet access to clinically characterized sporadic AD patient-derived cell models remains limited. To address this need, Axol Bioscience and StrataStem have developed a collection of sporadic Alzheimer’s disease (sAD) iPSC lines generated from donor PBMCs obtained with full ethical and commercial consent for research and cell manufacturing.
The collection comprises 20 iPSC lines from clinically characterized sAD patients and unaffected controls, including donors with APOE ε2/ε3, APOE ε3/ε3, APOE ε3/ε4, and APOE ε4/ε4 genotypes. Associated donor metadata includes diagnosis, age, sex, APOE genotype, and family and medical history, enabling patient stratification and cohort-based studies.
iPSC-derived cell types are available from selected donor lines, including cortical excitatory neurons, cortical inhibitory interneurons, astrocytes, and microglia. Early-access neural stem cell models representing multiple APOE genotypes are also available to support the development of genetically defined in vitro models of sporadic Alzheimer’s disease.
Key features
- 20 sporadic Alzheimer’s disease and unaffected control iPSC lines
- Full ethical and commercial consent for research and manufacturing applications
- Clinically characterized donor cohort with accompanying patient metadata
- APOE ε2/ε3, ε3/ε3, ε3/ε4, and ε4/ε4 genotypes represented
- Age- and sex-diverse donor population relevant to late-onset Alzheimer’s disease
- Available as iPSC lines, neural stem cells, and differentiated neural cell types
| iPSC | ApoE Genotype | CSF Abeta | Family & Medical History (Y/N) | Age | Sex | Diagnosis |
| CENSOi004-E | E2/E3 | N/T | N | 40-50 | M | not affected at time of donation |
| CENSO-SS-i005-A | E2/E3 | N/T | Y | 73 | M | not affected at time of donation |
| CENSO-SS-i007-A | E2/E3 | N/T | Y | 77 | M | sAD |
| CENSOi070-A | E3/E3 | N/T | N | 59 | F | sAD |
| CENSOi058-A | E3/E3 | N/T | N | 45 | F | not affected at time of donation |
| CENSO-SS-i004-A | E3/E3 | N/T | Y | 81 | M | not affected at time of donation |
| CENSO-SS-i006-A | E3/E3 | N/T | Y | 70 | M | not affected at time of donation |
| CENSO-SS-i009-A | E3/E3 | N/T | Y | 80 | M | sAD |
| CENSO-SS-i010-A | E3/E3 | N/T | Y | 83 | M | sAD |
| CENSO-SS-i015-A | E3/E3 | N/T | Y | 79 | F | sAD |
| CENSOi074-A | E3/E4 | N/T | N | 60 | M | sAD |
| CENSOi077-C | E3/E4 | N/T | N | 52 | F | sAD |
| CENSO-SS-i001-A | E3/E4 | high | Y | 70 | M | sAD |
| CENSO-SS-i002-A | E3/E4 | high | Y | 77 | M | sAD |
| CENSO-SS-i003-A | E3/E4 | high | Y | 72 | M | sAD |
| CENSO-SS-i011-A | E3/E4 | N/T | Y | 74 | M | sAD |
| CENSO-SS-i013-A | E3/E4 | N/T | Y | 82 | M | sAD |
| CENSO-SS-i008-A | E4/E4 | N/T | Y | 69 | F | sAD |
| CENSO-SS-i012-A | E4/E4 | N/T | Y | 76 | F | sAD |
| Early Access | ApoE Genotype | NSCs | Cortical neuron kit | Diagnosis | Age | Sex |
| CENSO-SS-i009-A | E3/E3 | ax0109 | ax5109 | sAD | 80 | M |
| CENSOi070-A | E3/E3 | ax0170 | ax5170 | sAD | 59 | F |
| CENSOi074-A | E3/E4 | ax0174 | ax5174 | sAD | 60 | M |
| CENSOi077-C | E3/E4 | ax0177 | ax0177 | sAD | 52 | F |
| CENSO-SS-i012-A | E4/E4 | ax0110 | ax5110 | sAD | 76 | F |
iPSC-derived cells for AD modeling
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