Description
Build high-quality in vitro pain models in 21 days.
Ensure confidence in your workflow with high-quality axoCellsTM sensory neurons differentiated from human induced pluripotent stem cells (iPSCs). Derived from healthy consenting donor cord blood, our sensory neurons have been specifically developed for use in neurological microfluidics systems, nociception models and for assessing analgesic drug targets. Our robust, functionally-relevant sensory neurons express over 50 key ion channels and fuel world-leading microfluidic and “organ-on-chip” models.
Supporting quality and consistency
Confidently carry out your neural workflow with iPSCs manufactured in our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Join our customer base of top ten biopharma and academic institutions in building robust, physiologically relevant disease models for research and drug discovery.
How to get high functioning Sensory Neurons:
- You’ll need a Sensory Neuron Kit ax0157
- In this you’ll find Sensory Neuron Cells ax0055 (0.5M) and all reagents*
- Follow the protocol
- 21 days later you will have high functioning sensory neurons
*Additional third party components may be required. Be sure to check the protocol before you start using the sensory neuron kit.
Need a quote for this single product or for the whole cell + media + reagent kit? We’re here to help! Click the ‘get a quote’ button or send an email to operations@axolbio.com
Product Highlights
- Robust, relevant sensory neurons express over 50 of the key ion channels, including Nav1.7, TRPV1 and TRPA1
- Ensure confidence with high-quality cells manufactured in our ISO:9001-accredited production facility under rigorous quality control procedures
- Designed for use in microfluidics platforms and organ-on-chip devices to investigate PNS disorders, chronic pain and drug targets for pain relief
- Used by leading Biopharma and academic institutions around the world to fuel robust microfluidic platforms and disease models
We have two pack sizes available from one line: a newborn male, cord blood donor.
Applications
Our axoCellsTM sensory neurons have been specifically developed for use in microfluidics systems, organ-on-chip devices and for in vitro disease modelling.
We have a community of top ten biopharma and research institutes who use our sensory neurons to build powerful in vitro models, investigating disorders of the peripheral nervous system, chronic pain and analgesic drug screening.
Protocols
We offer a fully optimized cell culture system including tailored Sensory Maintenance Medium to promote the viability and maturation of sensory neurons for endpoint assays on glass or plastic.
Quality
We maintain or exceed industry-level quality with our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience.
All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Licenses & Consent
Axol has obtained all relevant licenses for reprogramming donor samples into iPSCs and differentiating these into sensory neurons for commercial use.
Patient samples used to create these neurons have been ethically sourced and consented for research and commercial use. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Chow SYA, et al. 2022. Human sensory neurons modulate melanocytes through secretion of RGMB. Cell Rep. 2022 Sep 20;40(12):111366. doi: 10.1016/j.celrep.2022.111366. PMID: 36130522.
Deng T, et al. 2023. Scalable generation of sensory neurons from human pluripotent stem cells. Stem Cell Reports. 2023 Apr 11;18(4):1030-1047. doi: 10.1016/j.stemcr.2023.03.006. PMCID: PMC10147831.
Media & Reagents
Ensure high-quality, mature sensory neurons in just 21 days with our fully optimized media Sensory Neuron Maximizer kit (ax0158) and Maturation Maximizer media supplement (ax0058). We also supply cells, all growth factors and coating materials as a kit Human iPSC-Derived Sensory Neuron Maximizer Kit (ax0157) with cells).
