Axol launches axoCellsTM ALS Toolbox
Axol Bioscience, leader in iPSC technology has launched the axoCellsTM ALS Toolbox to support drug discovery and research into Amyotrophic Lateral Sclerosis (ALS). The toolbox includes motor neurons from six different donor lines including two unaffected donors, one C9orf72 carrying donor (the sibling to the C9orf72 ALS donors), and three donors each carrying significant genotypes associated with ALS; SOD1, C9orf72 and TDP43.
Axol has also released an extensive functional characterization data set on the cells showing histology and neuronal activity as measured by spontaneous neuronal activity (SNA) and multi-electrode array (MEA) plus reproducibility data.
Frozen motor neuron precursors are supplied in a bundle kit along with optimized cell culture media and the company’s Accelerator media, which creates a more in-vivo like environment for cell maturation. Cells are thaw-to-assay-ready in 10 days and have proven performance within a range of endpoint assays including MEA.
“Axol has a long history working to support ALS drug discovery.” says Duncan Borthwick, Head of Sales and Marketing, “and with the launch of the axoCellsTM ALS Toolbox and functional characterization data set, we hope this contributes to successful outcomes in ALS research. The toolbox will be available for external customer use in addition to our service customers.”
Characterization data and product information is available here-
