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Society of Toxicology (SOT) 2018

Axol Bioscience Ltd

We are attending the SOT Annual Meeting 2018 in Texas, from 11-15 March 2018. We will be available throughout the conference at booth 760 as well as in our workshop, March 12. Join us!

We would be delighted to meet you

Make sure you stop by:

Our Booth #760
Our Workshop (find out more)
Our Poster (find out more)

  • Spheroid culture of motor neurons generates mature cells with axons of 1000-1600 µm in length
  • The motor neurons in this model form functional mature neuromuscular junctions with muscle fibers causing them to twitch and contract when stimulated
  • This new human-specific model is a platform for drug development against motor neuron disease

In landmark work published in Scientific Reports Rimington et al. describe how they have succeeded in recreating the mature adult NMJ using Axol’s motor neuron progenitor cells (ax0078).[1] The team hope their 3D human NMJ model will replace animal models and monolayer cellular models, improving the translation of therapies to the clinic.

The team built the 3D NMJ by encouraging ax0078 motor neurons to synapse with primary muscle tissue cells obtained from healthy male adult volunteers and cultured in a 3D matrix. To do this, the team adopted a 3D spheroid culture approach that had previously been successful when culturing motor neurons with vascular cells.[2]

Organised by Axol Bioscience

“Stem Cell-Derived Human Renal Cells for Compound Screening and Nephrotoxicity Prediction”

Monday March 12, 2018
15:00 – 16:00
Henry B. González Convention Center, Room 217B

Workshop Overview

Dr. Daniele Zink will speak on the generation of human iPSC-derived Renal Proximal Tubular cells , the development of the first pre-validated screening platforms for accurate prediction of nephrotoxicity in humans, and the potential applications of these cells within drug discovery and toxicology with progression to future kidney-on-chip technologies for dose response prediction.

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