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axoCells™ human iPSC-derived astrocytes (unaffected), male donor, aged 40-50, ≥1 million cells
axoCells™ human iPSC-derived astrocytes (unaffected), male donor, aged 40-50, ≥1 million cells for neuroscience research. Astrocytes made from iPSCs which were generated from a 40-50 year old male donor’s fibroblasts.
- Derived from human iPSCs
- Assay ready in just 2 days
- Express the key markers (GFAP and S100B) with low expression of Nestin (an NSC marker)
- Demonstrated functionality in advanced in vitro models
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RNAseq and TempO-Seq™ data available on request
Specifications
Number of cells ≥1 million cells
Donor Male, 40-50 year old
Genetics Healthy control
Description
axoCells Human iPSC-Derived Astrocytes (≥1 million cells) for neuroscience research. Astrocytes made from iPSCs which were generated from a 40-50 year old male donor’s fibroblasts.
Key highlights include:
• Assay ready in just 2 days
• Express the key markers (GFAP and S100B) with low expression of Nestin (an NSC marker)
• Demonstrated functionality in advanced in vitro models
Top Resources
Additional Information
Marker Expression
The expression of these markers highlights that Axol’s Human iPSC astrocytes are physiologically representative of human primary astrocytes.
Applications
Our axoCellsTM astrocytes have been specifically developed for use in monoculture and complex co-culture systems for in vitro disease modeling and drug discovery.
We have a community of top ten biopharma and research institutes that use our astrocytes to build powerful in vitro models, investigating neurodegenerative disorders (Alzheimer’s, Parkinson’s and ALS) and drug screening.
Protocols
A fully validated protocol for monoculture of astrocytes is available.
Quality
We maintain or exceed industry-level quality with our ISO:9001-accredited production facility, guided by our rigorous quality control procedures and decades of scientific experience.
All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Licenses & Consent
Axol has obtained all relevant licenses for reprogramming donor samples into iPSCs and differentiating these into astrocytes for commercial use.
Patient samples used to create these cells have been ethically sourced and consented for research and commercial use. All cells come with a full Certificate of Analysis and are officially certified by HPSCreg®, to ensure ethical and biological conformity for your peace of mind.
Kumar, M.; Nguyen, N.T.P.; Milanese, M.; Bonanno, G. Insights into Human-Induced Pluripotent Stem Cell-Derived Astrocytes in Neurodegenerative Disorders. Biomolecules 2022, 12, 344. https://doi.org/10.3390/biom12030344
Barak, M., Fedorova, V., Pospisilova, V. et al. Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids. Stem Cell Rev and Rep 18, 792–820 (2022). https://doi.org/10.1007/s12015-021-10254-3
Media and Reagents
Media is prepared from standard reagents and Axol provide optimized coating (SureBond-XF ax0053) and growth factors for culture of astrocytes.
