Organ-on-a-chip Partnerships
Human iPSC-derived cells for microfluidic and organ-on-a-chip platform providers
Here at Axol, we use iPSCs to build more relevant models of human disease to expand your understanding and de-risk drug development. Our history and experience in this field date back to 2006 at the Roslin site in Edinburgh, famous for Dolly the sheep.
Central to the company’s capabilities is a library of human donor iPSCs, axoLines™, from which we offer out-sourcing iPSC-related project work in axoServices™, and highly consistent and quality differentiated end point axoCells™.
Axol are a major B2B supplier of cells to platform providers in the MPS, microfluidic and organ-on-a chip (OOC) space. We prioritize the consistency and quality of cell products, and the ease and speed of protocols; both are key to the overall partner and end-customer satisfaction, and we see your success closely linked to our success.
iPSCs and Microphysiological Systems – Technology Journal 2025
If you want to see cutting-edge in vitro systems – it’s right here!
In collaboration with 12 leading platform and technology providers, Axol Bioscience has brought together a set of applications notes issued as an iPSC and MPS Tech Journal.
Learn how iPSC-derived cells in conjunction with advanced in vitro modalities and genomic and functional endpoints is generating a new era of more human relevant systems to push forward research and drug discovery. The journal looks at a range of MPS systems, organoid platforms and multi-electrode array and genomic and transcriptomic assays in conjunction with iPSC-derived neurons, sensory cells and cardiac cells.
The Tech Journal will be launched at the premier MPS conference, MPS 2025 in Brussels in June. We thank our collaborators and friends: 3Brain, BiomimiX, CytoTronics, Systasy Bioscience, Ushio, Mimetas, Sygnature Discovery, Axion BioSystems, 4DCell, innoVitro, NETRI, Tessara Therapeutics
For more details, contact operations@axolbio.com
Contents
- Electrophysiological analysis of atrial and ventricular axoCells™ cardiomyocytes utilizing 3Brain’s CorePlate ™ enabled HD-MEA, 3Brain
- Beating heart-on-chip to model atrial and ventricular cardiac chambers, BiomimiX
- Advancing ALS Modeling: High-Dimensional Insights with CytoTronics’ Pixel, CytoTronics
- Pathway Profiling of axoCells Sensory Neurons, Systasy Bioscience
- Neurotoxicity Evaluation via Nerve MPS and Machine learning, Ushio
- A 3D neurite outgrowth model for studying motor axon biology, Mimetas
- A high content imaging screening assay to identify novel neuroinflammation modulators using human iPSC-derived microglia, Sygnature Discovery
- Multi-electrode array characterization of a human iPSC-derived motor neuron disease model for ALS drug discovery, Axion BioSystems
- SmartHeart: An innovative high-throughput assay to generate and assess cardiac micro tissues from hiPSCs, answering to the current challenges of cardiac toxicity and efficacy, 4DCell
- AF on Demand: A Human iPSC-Derived Screening Assay Targeting Atrial Fibrillation, innoVitro
- Characterizing sensory neurons as universal bio-digital sensor to explore PNS applications, NETRI
- Poster: Development of iPSC-derived 3D human brain micro-tissues for drug discovery applications, Tessara Therapeutics
Highlights
- Axol Bioscience is a leading supplier of cells used in microfluidic / MPS / OOC platforms
- Specialist in sensory and motor neurons
- We partner with platform providers to supply high-quality cells for R&D and commercial resale/ through-sale
- With our custom axoServicesTM offering, we offer in-house R&D project capabilities for platform providers, to accelerate your product development and delivery
Consistency is everything
Our Quality Management System is the bedrock for our daily work, driving quality and consistency for our customers. Bulk / same batch manufacturing and storage are available.
- Our manufacturing facilities are ISO 9001:2015 accredited
- We conduct in-depth iPSC characterisation, both pre- and post-differentiation
- Our Certificate of Analysis inserts report on the quality testing methods and results
- We provide full batch control and options of ownership
- There is full traceability of material origin and source
- We utilise a Q-Pulse Quality Management System for compliant audit-trail operation
Cell types
Our axoCells™ product portfolio includes five focus areas where we provide cells, media, and reagents:
- iPSC-derived cells for Neuroscience: neuronal, glial, and neuroinflammatory cells
- iPSC-derived cells for Ophthalmology: epithelial and neuroinflammatory cells
- iPSC-derived cells for Cardiovascular toxicity and research: cardiac muscle cells
- iPSC-derived cells for Pain & Sensation studies: sensory neurons
- iPSC-derived cells for Dermatology and Cosmetics: skin and sensory cells
Let’s talk
We look forward to building further relationships in this market space and welcome enquiries to operations@axolbio.com ahead of a confidential discussion.
Learn more
• https://axolbio.com/publications/netri-axol-bioscience-press-release-january-10th-2023/
• Leung, C.M., de Haan, P., Ronaldson-Bouchard, K. et al. A guide to the organ-on-a-chip. Nat Rev Methods Primers 2, 33 (2022). https://doi.org/10.1038/s43586-022-00118-6