In vitro disease modelling

Modelling human disease through cell culture

In vitro disease modeling with human iPSCs aims create laboratory models of diseases, which can be used to study the underlying mechanisms of a disease, test potential treatments, and ultimately, to develop new therapies. Stem cells are unique in that they can be induced to differentiate into various types of cells found in the body, including those affected by a specific disease. By differentiating stem cells into the cells affected by a disease, scientists can create a laboratory model that closely mimics the disease in vivo, allowing for a more accurate understanding of the disease and the potential efficacy of new treatments. This approach also allows scientists to study diseases that are difficult to study in vivo, such as neurodegenerative diseases, and to study the progression of a disease over time.

Modelling complexity through cell culture

iPSC technology enables the derivation of functional endpoint cells from human donor cells, in volume at a robust and controlled Quality environment. From this supply, the creation complex co-cultures in 2D, 3D and in microfluidic frameworks, to act as a physiologically relevant surrogate for diseased tissue is possible.

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https://link.springer.com/journal/44164/volumes-and-issues/1-6