Frontotemporal dementia and Parkinson’s Disease cellular models: In vitro characterization of pathological phenotypes in gene-edited iPSC-derived neurons with MAPT and LRRK2 mutations

Mutations in MAPT and LRRK2 are reported to play a causative role in familial forms of frontotemporal dementia and Parkinson’s disease respectively. Human cell-based models in which to investigate the effect of these mutations on cellular functions such as microtubule…