Human iPSC-Derived Motor Neuron Progenitors (C9ORF72 expansion)
Axol’s Human iPSC-Derived Motor Neuron Progenitors from a healthy male donor carrying C9orf72 hexanucleotide expansion. The repeat expansion of the parental iPSC line of the motor neuron progenitor was determined by Southern blot.
C9orf72 is present in ~ 40% of familial ALS and 8-10 % of sporadic ALS. It is the most common mutation related to ALS – far more common than SOD1 or TDP-43.
|Donor mutation||C9ORF72 repeat expansion|
|Starting material||Dermal fibroblast|
|Donor age at sampling||62 yrs|
|Reprogramming method||Sendai Virus|
|Size||≥2 million cells|
|Shipping conditions||Dry ice|
|Storage conditions||Liquid nitrogen|
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