BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues.
|Purity||Verified by SDS-PAGE and, where possible, by RP-HPLC|
|Shipping conditions||Ambient temperature|
|Storage conditions||See CoA shipped with product|
|Endotoxin level||< 0.1 ng/μg of protein (< 1 EU/μg)|
|Reconstitution||See CoA shipped with product|
|Stability||See CoA shipped with product|