Nasu-Hakola Disease

Associated with mutations in the TREM2 and TYROBP genes, Nasu-Hakola disease (NHD), also referred to as polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare inherited leukodystrophy.

Axol’s Nasu Hakola disease lines are derived from patients and are excellent models for investigating the disease.

Axol now offers made-to-order differentiated human iPS brain cells, such as microglia, from these NHD lines.

Donor Condition	Lines Available
Nasu-Hakola Disease	Female, 41, TREM2: Hom. c.150G>T p.(W50C)
	Female, 69, TREM2: Het. c.150G>T p.(W50C) (Asymptomatic Carrier)
	Male, 68, TREM2: Het. c.150G>T p.(W50C) (Asymptomatic Carrier)