Our iPSC-derived astrocytes are cryopreserved for convenience, and they are assay-ready within 48 hrs. Once thawed, Axol’s astrocytes display all indicative astrocytic markers and will respond to glutamate stimulation, a key functional characteristic within 48-60 hrs. They also express markers showing that Axol’s Human iPSC-derived astrocytes are physiologically representative of human primary astrocytes.
Human iPSC-Derived Astrocytes
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Description
Human iPSC-Derived Astrocytes
Astrocyte dysfunction has been implicated in a number of neurological conditions such as Alzheimer’s and Parkinson’s diseases, autism, amyotrophic lateral sclerosis (ALS), Rett syndrome and schizophrenia.
Axol’s Human iPSC-derived astrocytes offer a convenient and physiologically-relevant tool to study these cells as an isolated population or within co-cultures of other neural cells for analysis of complex central nervous system (CNS) circuitry.
Axol’s Human iPSC-derived astrocytes express glial markers such as glial fibrillary acidic protein (GFAP), S100b, AQP4, ALDHL1L and EAAT1.
They have also been further validated for expression of other relevant markers including Vimentin, Kir4.1 (potassium channel) and CD44.
These cells exhibit low expression of Nestin, a marker of neural stem cells, and are tested to have very low or negative expression for MAP2, a marker of neurons.
Marker Expression
The expression of these markers highlights that Axol’s Human iPSC astrocytes are physiologically representative of human primary astrocytes.
Cellular Characteristics
Axol’s astrocytic population is comprised of a mixture of grey and white matter astrocytes with a preference towards WHITE MATTER, focusing on those cellular populations that modulate the distribution of action potentials coordinating communication between different brain regions, acting as a relay for input/output signals
MEA Characterization of Cerebral Cortical Neuron-Astrocyte Co-culture
Product Specification
| Bio-Safety Level | Level 1 |
| Starting material | iPSC-derived NSCs |
| Donor gender | Male |
| Donor age at sampling | Newborn |
| HLA serotype | A29 A68, B38(Bw4) B44(Bw4), Cw8 Cw12 |
| Karyotype | Normal |
| Reprogramming method | Episomal vector |
| Genetic modification | None |
| Size | 1 million cells / frozen vial |
| Growth properties | Adherent |
| Shipping conditions | Dry ice |
| Storage conditions | vapour phase nitrogen |
