Functional motor neurons from patient iPSC lines to support ALS research and drug discovery

Functional motor neurons from patient iPSC lines to support ALS research and drug discovery

Axol Bioscience, leader in iPSC technology had launched the axoCells ALS Toolbox to support drug discovery and research into amyotrophic lateral sclerosis (ALS). The toolbox includes motor neurons from six different donor lines including two unaffected donors, one C9orf72 carrying donor (a sibling to one of the ALS donors), and three donors each carrying significant genotypes associated with ALS, SOD1, C9orf72 and TDP43.

Axol has also released an extensive functional characterization data set on the cells showing histology and neuronal activity as measured by spontaneous neuronal activity (SNA) and multi-electrode array (MEA) plus reproducibility data.

Watch the axoCells ALS Toolbox Launch video