Analysis of axoCells atrial and ventricular cardiomyocytes electrophysiology using CorePlate enabled HD-MEA system
A 7-day thaw-to-data protocol comparing axoCells™ Atrial (ax2518) and Ventricular (ax2508) iPSC-derived Cardiomyocytes using 3Brain’s CorePlate™ enabled HD-MEA system.
Key findings:
- HD-MEA allows visualization of activity propagation across the plate
- BrainWave software accurately calculates key electrophysiological parameters such as field potential duration (FPD) and inter-beat interval
- Atrial cardiomyocytes have a shorter FPD than ventricular cardiomyocytes
- Atrial cardiomyocytes give the expected pharmacological response to isoprotenerol including increased frequency and shorter QT interval