Please be aware that Neural Plating Medium ax0033 (not Xeno-Free) may be needed for your specific order. Please be sure to include ax0033 if required.
axolGEM iPSC-Derived Neural Stem Cells MAPT V337M HOM
Human iPSC-Derived Neural Stem Cells that have been genetically edited using CRISPR-Cas9 technology to introduce the V337M mutation (GTG>ATG) in the MAPT gene. This line is homozygous for the V337M mutation so both alleles contain the mutation. Click on the product images to see the data and further details.
The V337M mutation in MAPT has been implicated in frontotemporal dementia and may have a role in Alzheimer’s disease. The mutation leads to accelerated aggregation of MAPT/tau protein into filament structures (Nacharaju et al., 1999) and makes the MAPT/tau protein more susceptible to hyperphosphorylation (Alonso et al., 2004).