Axol iPSC-Derived Renal Proximal Tubular Cells are derived from integration-free iPSCs of a healthy male donor and have been differentiated through the up-regulation of specific signalling pathways. To support the growth and maintenance of Axol iPSC-Derived Renal Proximal Tubular Cells, we offer our Renal Epithelial Cell Culture Medium which is fully supplemented with hormones and recombinant growth factors that promote optimal growth.
Our iPSC-Derived Renal Proximal Tubular Cells express critical functional markers, along with epithelial and renal cell markers. These include the important phosphate transporter, SLC34A1, the organic ion transporter crucial for baso-lateral uptake of organic anions, OAT1 and the apical glucose transporter SGLT2, key in glucose reabsorption from the glomerular filtrate. These cells provide a physiologically relevant model for investigating glucose uptake in diabetes, the transportation of drugs and endogenous metabolites, and detecting nephrotoxicity. Axol iPSC-Derived Renal Proximal Tubular Cells are ready for endpoint assays within 4 days of plating providing an easy-to-use, assay-ready system for cell based assays.