Axol iPSC-Derived Macrophages are derived from iPSCs that have undergone an intermediate differentiation to monocytes prior to directed terminal differentiation to macrophages.
This provides a highly pure and consistently reproducible population of macrophages. To support the growth and maintenance of Axol iPSC-Derived Macrophages, we offer a chemically defined, serum-free, fully optimized Macrophage Maintenance Medium.
One of the key functions of macrophages is to clean up! More specifically, by engulfing and destroying foreign substances, cell debris and microbes. Our iPSC-Derived Macrophages are highly phagocytic and express the ionized calcium-binding adapter molecule 1 (IBA1), which is typically expressed by macrophages upon activation.
When recruited to the site of injury and infection macrophages have the ability to differentiate to specific macrophage subtypes dependent on their location within the body. Within the lungs, pulmonary macrophages are a good example of tissue-specific macrophages, these cells function to protect the lungs by removing inhaled and deposited particles. iPSC-derived macrophages could be used in co-culture to model and investigate tissue-specific macrophages.
Axol iPSC-Derived Macrophages are shipped live providing an easy-to-use, assay-ready system for modeling inflammatory and immune responses.